Occasionally, Sales Automation Manager (SAM) will not open because of a Windows update or process that corrupts a key configuration file. You can get SAM working again by deleting this file. Note - if you have made customization to the settings (in the advanced tab) you will need to reset them.
The file lives in %appdata%\Northwoods Software\SalesAutomationManager
The filename is samsettings.txt. This is the file you should delete and then reopen SAM.